Saturday, 29 September 2018

Most devastating infections of the Nervous System

There is far more in Neurology than Neuroinflammation and Neurodegenerative disorders as only these disorders earn a lot of attention. But infections also impose a lot of burden on Neurological practice than Multiple Sclerosis or Parkinson's Disease. There are very less medical advances to prevent these creatures from invading the nervous system.

The major types of organisms that infect the nervous system include bacteria and virus, while fungi and parasites may also cause infections.

Following is a list of the most devastating viral and bacterial infections of the nervous system:

  1. Viral encephalitis
  2. HIV associated neurological infections
  3.  Hepatitis E Virus (HEV)
  4. Influenza H1N1
  5. Zika Virus infection (ZIKV)
  6. Eblola Virus Disease (EVD)
  7. Varicella Zoster Virus (VZV)

  1. Neurosyphilis
  2. Nervous system Tuberculosis
  3. Bacterial Meningitis
  4. Lyme Neuroborreliosis
  5. Botulism
  6. Neurobrucellosis
  7. Leprosy

Tuesday, 25 September 2018

Administered early, an already approved drug may help stop Alzheimer’s progression


The Alzheimer's disease research community is in a great deal of flux at the moment. After a series of high-profile clinical trial failures, rages over whether the current causal hypothesis for the disease is correct. A new study has revealed novel insights into the early stages of the disease's development and suggests treatment may only be effective if delivered before a person becomes symptomatic.
For several decades the generally agreed hypothesis regarding the main symptomatic cause behind the degenerative effects of Alzheimer's disease was that the build-up of plaques, composed of a protein called beta-amyloid, resulted in the systematic destruction of neurons. But the big problem that has arisen is that almost all efforts to target this amyloid build up, in one way or another, have failed. An astounding 99.6 percent of clinical trials into drugs to help beat Alzheimer's have failed.
Attempting to better explain why amyloid-targetingdrugs are failing in trials, some scientists are beginning to suggest the disease in the subjects in these trials may have progressed too far to respond effectively.

Saturday, 22 September 2018

Evidence Mounts That Germs May Cause Alzheimer's


In the end it will be microbes’ bacteria, viruses and fungus found to be at the root of all disease and aging, and specifically Alzheimer’s, contends geneticist Dr. Rudolph “Rudy” Emile Tanzi.

“The two biggest threats to healthy aging have had to do with dealing with infection,” said Tanzi, who specializes in Alzheimer’s and the brain at Massachusetts General Hospital (MGH) and Harvard Medical School. “Think about it. When we increased the lifespan from 35 to 50, it was by covering the sewers. When we increased the lifespan from 50 to 75, it was with the use of antibiotics. Now we are looking for viruses in all of the major life-threatening diseases of our time Alzheimer’s, cancer, Parkinson’s and guess what? Infection is now cropping up in all of them.”

And though evidence continues to mount that could prove his theory, Tanzi says scientists are just beginning to scratch the surface of the culprits that can trigger the spiral into Alzheimer’s disease.



Tuesday, 18 September 2018

Marijuana compound removes toxic Alzheimer’s protein from the brain

Salk Institute scientists have found preliminary evidence that tetrahydrocannabinol (THC) and other compounds found in marijuana can promote the cellular removal of amyloid beta, a toxic protein associated with Alzheimer’s disease.
“Although other studies have offered evidence that cannabinoids might be neuroprotective against the symptoms of Alzheimer’s, we believe our study is the first to demonstrate that cannabinoids affect both inflammation and amyloid beta accumulation in nerve cells,” says Salk Professor David Schubert, the senior author of the paper.
THC is responsible for the majority of marijuana’s psychological effects, including the high, due to its natural pain-relieving properties.
Salk researchers have found that high levels of amyloid beta were associated with cellular inflammation and higher rates of neuron death. They demonstrated that exposing the cells to THC reduced amyloid beta protein levels and eliminated the inflammatory response from the nerve cells caused by the protein, thereby allowing the nerve cells to survive.
To discuss on more enthralling topics on Neurology, join the "7th International Conference on Neurology and Neuromuscular Diseases" that is slated on October 22-23, 2018 at Madrid, Spain. Submit your abstracts and be a speaker, visit: https://bit.ly/2P4wozp

Saturday, 15 September 2018

Chiari Malformation Type 1

Chiari Malformation Type 1 shows symptoms usually during late childhood or adulthood. This malformation occurs during fetal development and is characterized by downward displacement (more than four millimeters) of the cerebellar tonsils beneath the foramen magnum into the cervical spinal canal. This displacement may block the normal pulsations of CSF between the spinal canal and the intracranial space.

Headaches, which are often severe are the classical symptoms of Type 1 condition. This occurs generally after sudden coughing, sneezing or straining. People may also experience neck pain, dizziness, numbness and tingling in arms and feet, unsteady gait, difficulty swallowing, poor hand coordination, speech and vision problems.
As this type 1 occurs as the skull and brain are growing, signs and symptoms occur only during late childhood or adulthood. Depending on the symptoms present and severity, some individuals may not require treatment while others may require pain medications or surgery.


chiari-graph

Wednesday, 12 September 2018

Hemiplegic Migraine

Hemiplegic migraine is a serious type of migraine headache, most symptoms of which mimics those of stroke. A person with hemiplegic migraine will experience weakness in one side of the body which causes temporary paralysis which doctors often call, hemiplegia. The weakness can involve face, arm, or legs along with numbness, tinlgling and needles. The person can experience speech and vision problems or confusion. This weakness may last from one hour to several days, but usually it goes within 24 hours. The head pain associated with migraine typically follows the weakness, but the headache may precede it or be absent.

There are two types of hemiplegic migraine- Familial Hemiplegic Migraine (FHM) and Sporadic Hemiplegic Migraine (SHM)

Causes: There are four genes related to familial hemiplegic migraine: CACNA1A, ATP1A2, SCN1A, and possibly PRRT2. These genes are related to channels on nerve membranes that control the movement of substances like sodium, calcium and potassium across the nerve. Mutations of these genes result in over-excitability of nerves.
People with Sporadic migraine will experience all the physical symptoms of FHM but doesn’t have a known familial connection.

To share and gain knowledge on the various aspects of neurology, join the "7th International Conference on Neurology and  Neuromuscular Diseases" that will be held on October 22-23, 2018 at Madrid, Spain. To know more, visit: https://bit.ly/2I9Frf7